New paper published in Experimental PhysiologyAugust 21, 2022 The paper is entitled: "Effect of adrenaline on serum mid-regional pro-atrial natriuretic peptide and central blood volume" and is based on a subgroup of patients from the EFEX-OA-02 study, registered at clinicaltrials.org (registration no. NCT04542668)
What is the central question in this study? Atrial natriuretic peptide (ANP) is secreted in response to atrial wall distension and thus allows for evaluation, albeit indirect, of the central blood volume. Adrenaline has chronotropic and inotropic effects. We evaluated whether the chronotropic and inotropic effects of adrenaline were reflected in mid-regional proANP. What is the main finding and its importance? Central blood volume remained stable with infusion of adrenaline and yet mid-regional proANP increased. Thus, the chronotropic and inotropic state of the heart or adrenaline directly induces release of ANP variants from the myocytes.