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8 publications found
August 21, 2022
What is the central question in this study? Atrial natriuretic peptide (ANP) is secreted in response to atrial wall distension and thus allows for evaluation, albeit indirect, of the central blood volume. Adrenaline has chronotropic and inotropic effects. We evaluated whether the chronotropic and inotropic effects of adrenaline were reflected in mid-regional proANP. What is the main finding and its importance? Central blood volume remained stable with infusion of adrenaline and yet mid-regional proANP increased. Thus, the chronotropic and inotropic state of the heart or adrenaline directly induces release of ANP variants from the myocytes.
August 05, 2022
Associations between single-question Visual Analogue Scale pain score and weight-bearing and non-weight-bearing domains of Western Ontario and McMaster Universities Arthritis Index pain: data from 2 phase 3 clinical trials
The objective of this cross-sectional study was to explore the associations between single-question VAS pain and the weight-bearing and non-weight-bearing domains of WOMAC pain. Data from 2093 patients with OA participating in 2 phase 3 clinical trials were included for post hoc analyses. Univariate Pearson correlations and comparison of r values were made using z statistics obtained using the Fisher r to z test for all items of the VAS pain scale, the WOMAC pain subscale, the weight-bearing and non-weight-bearing constructs of WOMAC pain subscale, and by subgroups of WOMAC pain quintiles and Kellgren-Lawrence grades.
Bjerre-Bastos JJ , Miller CP , Li Y , Andersen JR , Karsdal MA , Bihlet AR
July 22, 2022
An Estimate of Plasma Volume Changes Following Moderate-High Intensity Running and Cycling Exercise and Adrenaline Infusion
Plasma volume (PV) changes in response to physical activity, possibly as a consequence of adrenergic activation. We estimated changes in PV in response to common exercise modalities; cycling and running as well as adrenaline infusion and control at rest.
Journals:Frontiers in Physiology
Bjerre-Bastos JJ , Sejersen C , Bihlet AR , Secher NH , Mackey AL , Kitchen CC , Drobinski P , Thudium CS , Nielsen HB
June 22, 2021
A biomarker perspective on the acute effect of exercise with and without impact on joint tissue turnover: an exploratory randomized cross-over study
To investigate acute changes in biochemical markers of bone and cartilage turnover in response to moderate intensity exercise with and without joint impact in healthy human subjects.
Journals:European Journal of Applied Physiology
Bjerre-Bastos JJ , Nielsen HB , Andersen JR , Karsdal MA , Boesen M , Mackey AL , Byrjalsen I , Thudium CS , Bihlet AR
March 03, 2021
Does moderate intensity impact exercise and non-impact exercise induce acute changes in collagen biochemical markers related to osteoarthritis? - An exploratory randomized cross-over trial
To investigate acute changes in biochemical markers of cartilage turnover in response to moderate intensity exercise with and without joint impact in humans with knee osteoarthritis.
Journals:Osteoarthritis and Cartilage
March 20, 2020
Clinical and biochemical factors associated with risk of total joint replacement and radiographic progression in osteoarthritis: Data from two phase III clinical trials
Clinical trials of new disease-modifying treatments for osteoarthritis should demonstrate a positive effect on a functional outcome or reduction in joint failure in order to be considered successful. Total joint replacement (TJR) surgery may be considered as joint failure, but great variation in the incidence of TJR complicates its use as a study endpoint. Factors predicting elevated risk of TJR could potentially be used to enrich such outcome-trials.
Journals:Seminars in Arthritis and Rheumatism
March 20, 2020
The acute and long-term impact of physical activity on biochemical markers and MRI measures in osteoarthritis—Perspectives for clinical osteoarthritis research
We aimed to investigate existing literature on the impact of physical activity and exercise (PA) on joint biochemical markers (BM) and magnetic resonance imaging (MRI) outcomes in osteoarthritis (OA), and on this basis propose directions for future research. Literature Review. Original papers were identified in PubMed, Embase, and Scopus and data on study populations, activity, biomarkers, imaging, and outcomes were extracted and reviewed. 24 papers, mainly on knee OA, were included. PA indicated acute increase in cartilage turnover in OA patients, as indicated by changes in markers of extra cellular matrix (ECM) turnover.
Journals:Translational Sports Medicine
March 10, 2020
Evaluation of serum ARGS neoepitope as an osteoarthritis biomarker using a standardized model for exercise-induced cartilage extra cellular matrix turnover
To propose a standardized model for exercise-induced cartilage turnover and investigate residual levels and dynamics of biomarker serum ARGS (sARGS) in primary osteoarthritis (OA) patients and a supportive group of young healthy subjects.
Journals:Osteoarthritis and Cartilage Open
Bjerre-Bastos JJ , Nielsen HB , Andersen JR , He Y , Karsdal MA , Bay-Jensen AC , Boesen M , Mackey AL , Bihlet AR