Obesity & Metabolism

At NBCD, we're bridging Musculoskeletal Clinical Research with Obesity and Metabolic Diseases

One Partner, Two Pillars of Expertise

At NBCD, our legacy lies in deep, focused expertise in musculoskeletal clinical research. Recognizing the link between obesity and musculoskeletal disorders, NBCD integrates expertise from both areas to provide holistic insights. This dual specialization enhances our ability to design trials that consider the full spectrum of obesity-related complications.

We specialize in the design and execution of clinical trials for obesity and musculoskeletal disorders, combining decades of experience, scientific leadership, and operational excellence.

Whether you’re advancing therapies for weight-related conditions, muscle preservation, metabolic diseases, or mobility and joint health, we help you navigate the complexity of clinical development and deliver high-quality, efficient studies tailored to the demands of today’s obesity landscape.

Understanding Obesity and Its Related Diseases

Obesity affects billions of people worldwide and is a major driver of chronic disease, disability, and early death. More than 220 conditions are linked to obesity – highlighting its deep impact on organ systems and long-term health.

These conditions include: Type 2 diabetes, pre-diabetes, sleep apnea, dyslipidemia, osteoarthritis, and chronic back pain. Many have limited treatment options and remain areas of high unmet need.

The complexity of obesity has increased with the emergence of next-generation therapies. These treatments go beyond weight loss – targeting body composition, preserving muscle and bone mass, improving tolerability, and supporting long-term adherence.

As the field shifts toward more personalized treatment strategies, successful development requires focused therapeutic insight and scientific depth.

It’s exactly the kind of challenge we’re built to solve.

Navigating Next-Gen Obesity Trials

Obesity trials today demand more than just operational support. As therapies evolve toward personalized, mechanism-driven approaches, clinical design must keep pace. Sponsors face growing expectations around function, body composition, and long-term outcomes.

NBCD brings the therapeutic insight and operational precision needed to lead in this complexity.

Key Challenges We Solve

We address these challenges with tailored strategies, deep experience, and execution built for today’s trials.

Diverse patient populations with varied comorbidities
Functional endpoints impacted by BMI
Evolving measures: mobility, performance, QoL
Obesity phenotype stratification
Recruitment for sarcopenic or multi-comorbid patients
Regulatory ambiguity around novel endpoints

NBCD

Designing Smarter Obesity Trials

“Designing effective obesity trials today means thinking beyond weight loss. It’s about understanding phenotypes, managing comorbidities, and selecting endpoints that truly reflect patient outcomes.

At NBCD, we focus on generating high-quality data through well-designed, operationally sound studies – because the right evidence starts with the right execution.”

Sebastian M. N. Heimburger, PhD, Scientific Partnership Lead, Endocrinology & Obesity